Search results for "outer membrane vesicles"

showing 2 items of 2 documents

Extracellular vesicles in airway homeostasis and pathophysiology

2021

The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, inclu…

TechnologyCell typenanovesiclesQH301-705.5QC1-999Asthma Chronic obstructive pulmonary diseaseCOPDEpithelial–mesenchymal trophic unitExosomesMicrobiota Muco-microbiotic layer nanovesicles Outer membrane vesicles.Biologychronic obstructive pulmonary diseasePathogenesismedicineCOPDGeneral Materials ScienceBiology (General)QD1-999InstrumentationAsthmaFluid Flow and Transfer ProcessesCOPDSettore BIO/16 - Anatomia UmanaTPhysicsProcess Chemistry and TechnologyGeneral EngineeringasthmaEngineering (General). Civil engineering (General)medicine.diseasemuco-microbiotic layerMicrovesiclesPathophysiologyrespiratory tract diseasesComputer Science ApplicationsChemistryepithelial–mesenchymal trophic unitImmunologyTA1-2040AirwayHomeostasis
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Ekstracelulārās vezikulās ietvertās mikrobiālās RNS atklāšana cilvēku asins un urīna paraugos

2020

Gandrīz visi cilvēka šūnu tipi sekretē ekstracelulārās vezikulas (EVs), un tām ir svarīga loma starpšūnu komunikācijā. Jaunākie pētījumi liecina, ka komunikācija notiek arī starp cilvēka mikrobiotu un saimniekorganisma šūnām. Šajā pētījumā mēs parādām, ka no cilvēka asinīm un urīna izdalītās EVs satur RNS fragmentus no dažādiem mikroorganismiem. Visbiežāk sastopami baktēriju tipi un supertipi asinīs un urīnā bija Proteobacteria, PVC grupa un Terrabacteria. Lai noteiktu vai šo mikrobiālo transkriptu galvenais avots ir zarnu mikrobioms, mēs izstrādājām EV izdalīšanas metodi no cilvēku fēču paraugiem. Tālāk mēs plānojām veikt RNS sekvencēšanas (RNA-seq) analīzi EV, kas izdalītas no plazmas, ur…

bacterial transcriptomecell – free RNABioloģijaextracellular vesiclesouter membrane vesicles
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